Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein
Identifieur interne : 002036 ( Main/Exploration ); précédent : 002035; suivant : 002037Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein
Auteurs : Jose L. Nieto-Torres [Espagne] ; Marta L. Dediego [Espagne] ; Enrique Álvarez [Espagne] ; Jose M. Jiménez-Guarde O [Espagne] ; Jose A. Regla-Nava [Espagne] ; Mercedes Llorente [Espagne] ; Leonor Kremer [Espagne] ; Shen Shuo [Singapour] ; Luis Enjuanes [Espagne]Source :
- Virology [ 0042-6822 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Appareil de Golgi (métabolisme), Appareil de Golgi (virologie), Cellules Vero, Données de séquences moléculaires, Espace intracellulaire (métabolisme), Espace intracellulaire (virologie), Humains, Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (métabolisme), Réticulum endoplasmique (métabolisme), Réticulum endoplasmique (virologie), Syndrome respiratoire aigu sévère (métabolisme), Syndrome respiratoire aigu sévère (virologie), Transport de protéines, Virus du SRAS (génétique), Virus du SRAS (métabolisme).
- MESH :
- génétique : Protéines de l'enveloppe virale, Virus du SRAS.
- métabolisme : Appareil de Golgi, Espace intracellulaire, Protéines de l'enveloppe virale, Réticulum endoplasmique, Syndrome respiratoire aigu sévère, Virus du SRAS.
- virologie : Appareil de Golgi, Espace intracellulaire, Réticulum endoplasmique, Syndrome respiratoire aigu sévère.
- Animaux, Cellules Vero, Données de séquences moléculaires, Humains, Transport de protéines.
English descriptors
- KwdEn :
- Animals, Chlorocebus aethiops, Endoplasmic Reticulum (metabolism), Endoplasmic Reticulum (virology), Golgi Apparatus (metabolism), Golgi Apparatus (virology), Humans, Intracellular Space (metabolism), Intracellular Space (virology), Molecular Sequence Data, Protein Transport, SARS Virus (genetics), SARS Virus (metabolism), Severe Acute Respiratory Syndrome (metabolism), Severe Acute Respiratory Syndrome (virology), Vero Cells, Viral Envelope Proteins (genetics), Viral Envelope Proteins (metabolism).
- MESH :
- chemical , genetics : Viral Envelope Proteins.
- genetics : SARS Virus.
- metabolism : Endoplasmic Reticulum, Golgi Apparatus, Intracellular Space, SARS Virus, Severe Acute Respiratory Syndrome, Viral Envelope Proteins.
- virology : Endoplasmic Reticulum, Golgi Apparatus, Intracellular Space, Severe Acute Respiratory Syndrome.
- Animals, Chlorocebus aethiops, Humans, Molecular Sequence Data, Protein Transport, Vero Cells.
Abstract
Severe acute respiratory syndrome (SARS) coronavirus (CoV) envelope (E) protein is a transmembrane protein. Several subcellular locations and topological conformations of E protein have been proposed. To identify the correct ones, polyclonal and monoclonal antibodies specific for the amino or the carboxy terminus of E protein, respectively, were generated. E protein was mainly found in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) of cells transfected with a plasmid encoding E protein or infected with SARS-CoV. No evidence of E protein presence in the plasma membrane was found by using immunofluorescence, immunoelectron microscopy and cell surface protein labeling. In addition, measurement of plasma membrane voltage gated ion channel activity by whole-cell patch clamp suggested that E protein was not present in the plasma membrane. A topological conformation in which SARS-CoV E protein amino terminus is oriented towards the lumen of intracellular membranes and carboxy terminus faces cell cytoplasm is proposed.
Url:
DOI: 10.1016/j.virol.2011.03.029
PubMed: 21524776
PubMed Central: 4726981
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001569
- to stream Pmc, to step Curation: 001569
- to stream Pmc, to step Checkpoint: 000B13
- to stream PubMed, to step Corpus: 001524
- to stream PubMed, to step Curation: 001524
- to stream PubMed, to step Checkpoint: 001423
- to stream Ncbi, to step Merge: 002327
- to stream Ncbi, to step Curation: 002327
- to stream Ncbi, to step Checkpoint: 002327
- to stream Main, to step Merge: 002060
- to stream Main, to step Curation: 002036
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein</title>
<author><name sortKey="Nieto Torres, Jose L" sort="Nieto Torres, Jose L" uniqKey="Nieto Torres J" first="Jose L." last="Nieto-Torres">Jose L. Nieto-Torres</name>
<affiliation wicri:level="4"><nlm:aff id="af0005">Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université autonome de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Dediego, Marta L" sort="Dediego, Marta L" uniqKey="Dediego M" first="Marta L." last="Dediego">Marta L. Dediego</name>
<affiliation wicri:level="4"><nlm:aff id="af0005">Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université autonome de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Alvarez, Enrique" sort="Alvarez, Enrique" uniqKey="Alvarez E" first="Enrique" last="Álvarez">Enrique Álvarez</name>
<affiliation wicri:level="4"><nlm:aff id="af0005">Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université autonome de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Jimenez Guarde O, Jose M" sort="Jimenez Guarde O, Jose M" uniqKey="Jimenez Guarde O J" first="Jose M." last="Jiménez-Guarde O">Jose M. Jiménez-Guarde O</name>
<affiliation wicri:level="4"><nlm:aff id="af0005">Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université autonome de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Regla Nava, Jose A" sort="Regla Nava, Jose A" uniqKey="Regla Nava J" first="Jose A." last="Regla-Nava">Jose A. Regla-Nava</name>
<affiliation wicri:level="4"><nlm:aff id="af0005">Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université autonome de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Llorente, Mercedes" sort="Llorente, Mercedes" uniqKey="Llorente M" first="Mercedes" last="Llorente">Mercedes Llorente</name>
<affiliation wicri:level="3"><nlm:aff id="af0010">Protein Tools Unit, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Protein Tools Unit, Centro Nacional de Biotecnología (CNB-CSIC), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kremer, Leonor" sort="Kremer, Leonor" uniqKey="Kremer L" first="Leonor" last="Kremer">Leonor Kremer</name>
<affiliation wicri:level="3"><nlm:aff id="af0010">Protein Tools Unit, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Protein Tools Unit, Centro Nacional de Biotecnología (CNB-CSIC), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shuo, Shen" sort="Shuo, Shen" uniqKey="Shuo S" first="Shen" last="Shuo">Shen Shuo</name>
<affiliation wicri:level="1"><nlm:aff id="af0015">Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673</wicri:regionArea>
<wicri:noRegion>Singapore 138673</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name>
<affiliation wicri:level="4"><nlm:aff id="af0005">Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université autonome de Madrid</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21524776</idno>
<idno type="pmc">4726981</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726981</idno>
<idno type="RBID">PMC:4726981</idno>
<idno type="doi">10.1016/j.virol.2011.03.029</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">001569</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001569</idno>
<idno type="wicri:Area/Pmc/Curation">001569</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001569</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000B13</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B13</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:21524776</idno>
<idno type="wicri:Area/PubMed/Corpus">001524</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001524</idno>
<idno type="wicri:Area/PubMed/Curation">001524</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001524</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001423</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001423</idno>
<idno type="wicri:Area/Ncbi/Merge">002327</idno>
<idno type="wicri:Area/Ncbi/Curation">002327</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002327</idno>
<idno type="wicri:doubleKey">0042-6822:2011:Nieto Torres J:subcellular:location:and</idno>
<idno type="wicri:Area/Main/Merge">002060</idno>
<idno type="wicri:Area/Main/Curation">002036</idno>
<idno type="wicri:Area/Main/Exploration">002036</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein</title>
<author><name sortKey="Nieto Torres, Jose L" sort="Nieto Torres, Jose L" uniqKey="Nieto Torres J" first="Jose L." last="Nieto-Torres">Jose L. Nieto-Torres</name>
<affiliation wicri:level="4"><nlm:aff id="af0005">Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université autonome de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Dediego, Marta L" sort="Dediego, Marta L" uniqKey="Dediego M" first="Marta L." last="Dediego">Marta L. Dediego</name>
<affiliation wicri:level="4"><nlm:aff id="af0005">Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université autonome de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Alvarez, Enrique" sort="Alvarez, Enrique" uniqKey="Alvarez E" first="Enrique" last="Álvarez">Enrique Álvarez</name>
<affiliation wicri:level="4"><nlm:aff id="af0005">Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université autonome de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Jimenez Guarde O, Jose M" sort="Jimenez Guarde O, Jose M" uniqKey="Jimenez Guarde O J" first="Jose M." last="Jiménez-Guarde O">Jose M. Jiménez-Guarde O</name>
<affiliation wicri:level="4"><nlm:aff id="af0005">Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université autonome de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Regla Nava, Jose A" sort="Regla Nava, Jose A" uniqKey="Regla Nava J" first="Jose A." last="Regla-Nava">Jose A. Regla-Nava</name>
<affiliation wicri:level="4"><nlm:aff id="af0005">Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université autonome de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Llorente, Mercedes" sort="Llorente, Mercedes" uniqKey="Llorente M" first="Mercedes" last="Llorente">Mercedes Llorente</name>
<affiliation wicri:level="3"><nlm:aff id="af0010">Protein Tools Unit, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Protein Tools Unit, Centro Nacional de Biotecnología (CNB-CSIC), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kremer, Leonor" sort="Kremer, Leonor" uniqKey="Kremer L" first="Leonor" last="Kremer">Leonor Kremer</name>
<affiliation wicri:level="3"><nlm:aff id="af0010">Protein Tools Unit, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Protein Tools Unit, Centro Nacional de Biotecnología (CNB-CSIC), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shuo, Shen" sort="Shuo, Shen" uniqKey="Shuo S" first="Shen" last="Shuo">Shen Shuo</name>
<affiliation wicri:level="1"><nlm:aff id="af0015">Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673</wicri:regionArea>
<wicri:noRegion>Singapore 138673</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name>
<affiliation wicri:level="4"><nlm:aff id="af0005">Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus Universidad Autónoma de Madrid, 28049 Madrid</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université autonome de Madrid</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Virology</title>
<idno type="ISSN">0042-6822</idno>
<idno type="eISSN">1096-0341</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Chlorocebus aethiops</term>
<term>Endoplasmic Reticulum (metabolism)</term>
<term>Endoplasmic Reticulum (virology)</term>
<term>Golgi Apparatus (metabolism)</term>
<term>Golgi Apparatus (virology)</term>
<term>Humans</term>
<term>Intracellular Space (metabolism)</term>
<term>Intracellular Space (virology)</term>
<term>Molecular Sequence Data</term>
<term>Protein Transport</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (metabolism)</term>
<term>Severe Acute Respiratory Syndrome (metabolism)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Vero Cells</term>
<term>Viral Envelope Proteins (genetics)</term>
<term>Viral Envelope Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Appareil de Golgi (métabolisme)</term>
<term>Appareil de Golgi (virologie)</term>
<term>Cellules Vero</term>
<term>Données de séquences moléculaires</term>
<term>Espace intracellulaire (métabolisme)</term>
<term>Espace intracellulaire (virologie)</term>
<term>Humains</term>
<term>Protéines de l'enveloppe virale (génétique)</term>
<term>Protéines de l'enveloppe virale (métabolisme)</term>
<term>Réticulum endoplasmique (métabolisme)</term>
<term>Réticulum endoplasmique (virologie)</term>
<term>Syndrome respiratoire aigu sévère (métabolisme)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Transport de protéines</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines de l'enveloppe virale</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endoplasmic Reticulum</term>
<term>Golgi Apparatus</term>
<term>Intracellular Space</term>
<term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Appareil de Golgi</term>
<term>Espace intracellulaire</term>
<term>Protéines de l'enveloppe virale</term>
<term>Réticulum endoplasmique</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil de Golgi</term>
<term>Espace intracellulaire</term>
<term>Réticulum endoplasmique</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Endoplasmic Reticulum</term>
<term>Golgi Apparatus</term>
<term>Intracellular Space</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Chlorocebus aethiops</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Protein Transport</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules Vero</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Transport de protéines</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome (SARS) coronavirus (CoV) envelope (E) protein is a transmembrane protein. Several subcellular locations and topological conformations of E protein have been proposed. To identify the correct ones, polyclonal and monoclonal antibodies specific for the amino or the carboxy terminus of E protein, respectively, were generated. E protein was mainly found in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) of cells transfected with a plasmid encoding E protein or infected with SARS-CoV. No evidence of E protein presence in the plasma membrane was found by using immunofluorescence, immunoelectron microscopy and cell surface protein labeling. In addition, measurement of plasma membrane voltage gated ion channel activity by whole-cell patch clamp suggested that E protein was not present in the plasma membrane. A topological conformation in which SARS-CoV E protein amino terminus is oriented towards the lumen of intracellular membranes and carboxy terminus faces cell cytoplasm is proposed.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Almazan, F" uniqKey="Almazan F">F. Almazan</name>
</author>
<author><name sortKey="Dediego, M L" uniqKey="Dediego M">M.L. DeDiego</name>
</author>
<author><name sortKey="Galan, C" uniqKey="Galan C">C. Galan</name>
</author>
<author><name sortKey="Escors, D" uniqKey="Escors D">D. Escors</name>
</author>
<author><name sortKey="Alvarez, E" uniqKey="Alvarez E">E. Alvarez</name>
</author>
<author><name sortKey="Ortego, J" uniqKey="Ortego J">J. Ortego</name>
</author>
<author><name sortKey="Sola, I" uniqKey="Sola I">I. Sola</name>
</author>
<author><name sortKey="Zu Iga, S" uniqKey="Zu Iga S">S. Zuñiga</name>
</author>
<author><name sortKey="Alonso, S" uniqKey="Alonso S">S. Alonso</name>
</author>
<author><name sortKey="Moreno, J L" uniqKey="Moreno J">J.L. Moreno</name>
</author>
<author><name sortKey="Nogales, A" uniqKey="Nogales A">A. Nogales</name>
</author>
<author><name sortKey="Capiscol, C" uniqKey="Capiscol C">C. Capiscol</name>
</author>
<author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alvarez, E" uniqKey="Alvarez E">E. Alvarez</name>
</author>
<author><name sortKey="Dediego, M L" uniqKey="Dediego M">M.L. DeDiego</name>
</author>
<author><name sortKey="Nieto Torres, J L" uniqKey="Nieto Torres J">J.L. Nieto-Torres</name>
</author>
<author><name sortKey="Jimenez Guardeno, J M" uniqKey="Jimenez Guardeno J">J.M. Jimenez-Guardeno</name>
</author>
<author><name sortKey="Marcos Villar, L" uniqKey="Marcos Villar L">L. Marcos-Villar</name>
</author>
<author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arbely, E" uniqKey="Arbely E">E. Arbely</name>
</author>
<author><name sortKey="Khattari, Z" uniqKey="Khattari Z">Z. Khattari</name>
</author>
<author><name sortKey="Brotons, G" uniqKey="Brotons G">G. Brotons</name>
</author>
<author><name sortKey="Akkawi, M" uniqKey="Akkawi M">M. Akkawi</name>
</author>
<author><name sortKey="Salditt, T" uniqKey="Salditt T">T. Salditt</name>
</author>
<author><name sortKey="Arkin, I T" uniqKey="Arkin I">I.T. Arkin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chu, D K" uniqKey="Chu D">D.K. Chu</name>
</author>
<author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name>
</author>
<author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cornell, C T" uniqKey="Cornell C">C.T. Cornell</name>
</author>
<author><name sortKey="Kiosses, W B" uniqKey="Kiosses W">W.B. Kiosses</name>
</author>
<author><name sortKey="Harkins, S" uniqKey="Harkins S">S. Harkins</name>
</author>
<author><name sortKey="Whitton, J L" uniqKey="Whitton J">J.L. Whitton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corse, E" uniqKey="Corse E">E. Corse</name>
</author>
<author><name sortKey="Machamer, C E" uniqKey="Machamer C">C.E. Machamer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Haan, C A M" uniqKey="De Haan C">C.A.M. de Haan</name>
</author>
<author><name sortKey="Smeets, M" uniqKey="Smeets M">M. Smeets</name>
</author>
<author><name sortKey="Vernooij, F" uniqKey="Vernooij F">F. Vernooij</name>
</author>
<author><name sortKey="Vennema, H" uniqKey="Vennema H">H. Vennema</name>
</author>
<author><name sortKey="Pottier, P J M" uniqKey="Pottier P">P.J.M. Pottier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Jong, A S" uniqKey="De Jong A">A.S. de Jong</name>
</author>
<author><name sortKey="Visch, H J" uniqKey="Visch H">H.J. Visch</name>
</author>
<author><name sortKey="De Mattia, F" uniqKey="De Mattia F">F. de Mattia</name>
</author>
<author><name sortKey="Van Dommelen, M M" uniqKey="Van Dommelen M">M.M. van Dommelen</name>
</author>
<author><name sortKey="Swarts, H G" uniqKey="Swarts H">H.G. Swarts</name>
</author>
<author><name sortKey="Luyten, T" uniqKey="Luyten T">T. Luyten</name>
</author>
<author><name sortKey="Callewaert, G" uniqKey="Callewaert G">G. Callewaert</name>
</author>
<author><name sortKey="Melchers, W J" uniqKey="Melchers W">W.J. Melchers</name>
</author>
<author><name sortKey="Willems, P H" uniqKey="Willems P">P.H. Willems</name>
</author>
<author><name sortKey="Van Kuppeveld, F J" uniqKey="Van Kuppeveld F">F.J. van Kuppeveld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dediego, M L" uniqKey="Dediego M">M.L. DeDiego</name>
</author>
<author><name sortKey="Alvarez, E" uniqKey="Alvarez E">E. Alvarez</name>
</author>
<author><name sortKey="Almazan, F" uniqKey="Almazan F">F. Almazan</name>
</author>
<author><name sortKey="Rejas, M T" uniqKey="Rejas M">M.T. Rejas</name>
</author>
<author><name sortKey="Lamirande, E" uniqKey="Lamirande E">E. Lamirande</name>
</author>
<author><name sortKey="Roberts, A" uniqKey="Roberts A">A. Roberts</name>
</author>
<author><name sortKey="Shieh, W J" uniqKey="Shieh W">W.J. Shieh</name>
</author>
<author><name sortKey="Zaki, S R" uniqKey="Zaki S">S.R. Zaki</name>
</author>
<author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name>
</author>
<author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dediego, M L" uniqKey="Dediego M">M.L. DeDiego</name>
</author>
<author><name sortKey="Pewe, L" uniqKey="Pewe L">L. Pewe</name>
</author>
<author><name sortKey="Alvarez, E" uniqKey="Alvarez E">E. Alvarez</name>
</author>
<author><name sortKey="Rejas, M T" uniqKey="Rejas M">M.T. Rejas</name>
</author>
<author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name>
</author>
<author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drexler, J F" uniqKey="Drexler J">J.F. Drexler</name>
</author>
<author><name sortKey="Gloza Rausch, F" uniqKey="Gloza Rausch F">F. Gloza-Rausch</name>
</author>
<author><name sortKey="Glende, J" uniqKey="Glende J">J. Glende</name>
</author>
<author><name sortKey="Corman, V M" uniqKey="Corman V">V.M. Corman</name>
</author>
<author><name sortKey="Muth, D" uniqKey="Muth D">D. Muth</name>
</author>
<author><name sortKey="Goettsche, M" uniqKey="Goettsche M">M. Goettsche</name>
</author>
<author><name sortKey="Seebens, A" uniqKey="Seebens A">A. Seebens</name>
</author>
<author><name sortKey="Niedrig, M" uniqKey="Niedrig M">M. Niedrig</name>
</author>
<author><name sortKey="Pfefferle, S" uniqKey="Pfefferle S">S. Pfefferle</name>
</author>
<author><name sortKey="Yordanov, S" uniqKey="Yordanov S">S. Yordanov</name>
</author>
<author><name sortKey="Zhelyazkov, L" uniqKey="Zhelyazkov L">L. Zhelyazkov</name>
</author>
<author><name sortKey="Hermanns, U" uniqKey="Hermanns U">U. Hermanns</name>
</author>
<author><name sortKey="Vallo, P" uniqKey="Vallo P">P. Vallo</name>
</author>
<author><name sortKey="Lukashev, A" uniqKey="Lukashev A">A. Lukashev</name>
</author>
<author><name sortKey="Muller, M A" uniqKey="Muller M">M.A. Muller</name>
</author>
<author><name sortKey="Deng, H" uniqKey="Deng H">H. Deng</name>
</author>
<author><name sortKey="Herrler, G" uniqKey="Herrler G">G. Herrler</name>
</author>
<author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name>
</author>
<author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name>
</author>
<author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name>
</author>
<author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S. van der Werf</name>
</author>
<author><name sortKey="Brodt, H R" uniqKey="Brodt H">H.R. Brodt</name>
</author>
<author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name>
</author>
<author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H. Rabenau</name>
</author>
<author><name sortKey="Panning, M" uniqKey="Panning M">M. Panning</name>
</author>
<author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L. Kolesnikova</name>
</author>
<author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name>
</author>
<author><name sortKey="Berger, A" uniqKey="Berger A">A. Berger</name>
</author>
<author><name sortKey="Burguiere, A M" uniqKey="Burguiere A">A.M. Burguiere</name>
</author>
<author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J. Cinatl</name>
</author>
<author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name>
</author>
<author><name sortKey="Escriou, N" uniqKey="Escriou N">N. Escriou</name>
</author>
<author><name sortKey="Grywna, K" uniqKey="Grywna K">K. Grywna</name>
</author>
<author><name sortKey="Kramme, S" uniqKey="Kramme S">S. Kramme</name>
</author>
<author><name sortKey="Manuguerra, J C" uniqKey="Manuguerra J">J.C. Manuguerra</name>
</author>
<author><name sortKey="Muller, S" uniqKey="Muller S">S. Muller</name>
</author>
<author><name sortKey="Rickerts, V" uniqKey="Rickerts V">V. Rickerts</name>
</author>
<author><name sortKey="Sturmer, M" uniqKey="Sturmer M">M. Sturmer</name>
</author>
<author><name sortKey="Vieth, S" uniqKey="Vieth S">S. Vieth</name>
</author>
<author><name sortKey="Klenk, H D" uniqKey="Klenk H">H.D. Klenk</name>
</author>
<author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name>
</author>
<author><name sortKey="Schmitz, H" uniqKey="Schmitz H">H. Schmitz</name>
</author>
<author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name>
</author>
<author><name sortKey="Almazan, F" uniqKey="Almazan F">F. Almazan</name>
</author>
<author><name sortKey="Sola, I" uniqKey="Sola I">I. Sola</name>
</author>
<author><name sortKey="Zuniga, S" uniqKey="Zuniga S">S. Zuniga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name>
</author>
<author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A.E. Gorbalenya</name>
</author>
<author><name sortKey="De Groot, R J" uniqKey="De Groot R">R.J. de Groot</name>
</author>
<author><name sortKey="Cowley, J A" uniqKey="Cowley J">J.A. Cowley</name>
</author>
<author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name>
</author>
<author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ewart, G D" uniqKey="Ewart G">G.D. Ewart</name>
</author>
<author><name sortKey="Sutherland, T" uniqKey="Sutherland T">T. Sutherland</name>
</author>
<author><name sortKey="Gage, P W" uniqKey="Gage P">P.W. Gage</name>
</author>
<author><name sortKey="Cox, G B" uniqKey="Cox G">G.B. Cox</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frank, R" uniqKey="Frank R">R. Frank</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galfre, G" uniqKey="Galfre G">G. Galfre</name>
</author>
<author><name sortKey="Milstein, C" uniqKey="Milstein C">C. Milstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Godet, M" uniqKey="Godet M">M. Godet</name>
</author>
<author><name sortKey="L Haridon, R" uniqKey="L Haridon R">R. L'Haridon</name>
</author>
<author><name sortKey="Vautherot, J F" uniqKey="Vautherot J">J.F. Vautherot</name>
</author>
<author><name sortKey="Laude, H" uniqKey="Laude H">H. Laude</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gosert, R" uniqKey="Gosert R">R. Gosert</name>
</author>
<author><name sortKey="Kanjanahaluethai, A" uniqKey="Kanjanahaluethai A">A. Kanjanahaluethai</name>
</author>
<author><name sortKey="Egger, D" uniqKey="Egger D">D. Egger</name>
</author>
<author><name sortKey="Bienz, K" uniqKey="Bienz K">K. Bienz</name>
</author>
<author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name>
</author>
<author><name sortKey="Ito, N" uniqKey="Ito N">N. Ito</name>
</author>
<author><name sortKey="Tseng, C T" uniqKey="Tseng C">C.T. Tseng</name>
</author>
<author><name sortKey="Makino, S" uniqKey="Makino S">S. Makino</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name>
</author>
<author><name sortKey="Peters, C J" uniqKey="Peters C">C.J. Peters</name>
</author>
<author><name sortKey="Makino, S" uniqKey="Makino S">S. Makino</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ji, H L" uniqKey="Ji H">H.L. Ji</name>
</author>
<author><name sortKey="Song, W" uniqKey="Song W">W. Song</name>
</author>
<author><name sortKey="Gao, Z" uniqKey="Gao Z">Z. Gao</name>
</author>
<author><name sortKey="Su, X F" uniqKey="Su X">X.F. Su</name>
</author>
<author><name sortKey="Nie, H G" uniqKey="Nie H">H.G. Nie</name>
</author>
<author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y. Jiang</name>
</author>
<author><name sortKey="Peng, J B" uniqKey="Peng J">J.B. Peng</name>
</author>
<author><name sortKey="He, Y X" uniqKey="He Y">Y.X. He</name>
</author>
<author><name sortKey="Liao, Y" uniqKey="Liao Y">Y. Liao</name>
</author>
<author><name sortKey="Zhou, Y J" uniqKey="Zhou Y">Y.J. Zhou</name>
</author>
<author><name sortKey="Tousson, A" uniqKey="Tousson A">A. Tousson</name>
</author>
<author><name sortKey="Matalon, S" uniqKey="Matalon S">S. Matalon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaplan, J H" uniqKey="Kaplan J">J.H. Kaplan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kearney, J F" uniqKey="Kearney J">J.F. Kearney</name>
</author>
<author><name sortKey="Radbruch, A" uniqKey="Radbruch A">A. Radbruch</name>
</author>
<author><name sortKey="Liesegang, B" uniqKey="Liesegang B">B. Liesegang</name>
</author>
<author><name sortKey="Rajewsky, K" uniqKey="Rajewsky K">K. Rajewsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuo, L" uniqKey="Kuo L">L. Kuo</name>
</author>
<author><name sortKey="Masters, P S" uniqKey="Masters P">P.S. Masters</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name>
</author>
<author><name sortKey="Moore, M J" uniqKey="Moore M">M.J. Moore</name>
</author>
<author><name sortKey="Vasilieva, N" uniqKey="Vasilieva N">N. Vasilieva</name>
</author>
<author><name sortKey="Sui, J" uniqKey="Sui J">J. Sui</name>
</author>
<author><name sortKey="Wong, S K" uniqKey="Wong S">S.K. Wong</name>
</author>
<author><name sortKey="Berne, M A" uniqKey="Berne M">M.A. Berne</name>
</author>
<author><name sortKey="Somasundaran, M" uniqKey="Somasundaran M">M. Somasundaran</name>
</author>
<author><name sortKey="Sullivan, J L" uniqKey="Sullivan J">J.L. Sullivan</name>
</author>
<author><name sortKey="Luzuriaga, K" uniqKey="Luzuriaga K">K. Luzuriaga</name>
</author>
<author><name sortKey="Greenough, T C" uniqKey="Greenough T">T.C. Greenough</name>
</author>
<author><name sortKey="Choe, H" uniqKey="Choe H">H. Choe</name>
</author>
<author><name sortKey="Farzan, M" uniqKey="Farzan M">M. Farzan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liao, Y" uniqKey="Liao Y">Y. Liao</name>
</author>
<author><name sortKey="Lescar, J" uniqKey="Lescar J">J. Lescar</name>
</author>
<author><name sortKey="Tam, J P" uniqKey="Tam J">J.P. Tam</name>
</author>
<author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liao, Y" uniqKey="Liao Y">Y. Liao</name>
</author>
<author><name sortKey="Yuan, Q" uniqKey="Yuan Q">Q. Yuan</name>
</author>
<author><name sortKey="Torres, J" uniqKey="Torres J">J. Torres</name>
</author>
<author><name sortKey="Tam, J P" uniqKey="Tam J">J.P. Tam</name>
</author>
<author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lim, K P" uniqKey="Lim K">K.P. Lim</name>
</author>
<author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Madan, V" uniqKey="Madan V">V. Madan</name>
</author>
<author><name sortKey="Castello, A" uniqKey="Castello A">A. Castello</name>
</author>
<author><name sortKey="Carrasco, L" uniqKey="Carrasco L">L. Carrasco</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maeda, J" uniqKey="Maeda J">J. Maeda</name>
</author>
<author><name sortKey="Repass, J F" uniqKey="Repass J">J.F. Repass</name>
</author>
<author><name sortKey="Maeda, A" uniqKey="Maeda A">A. Maeda</name>
</author>
<author><name sortKey="Makino, S" uniqKey="Makino S">S. Makino</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Masters, P S" uniqKey="Masters P">P.S. Masters</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, M A" uniqKey="Muller M">M.A. Muller</name>
</author>
<author><name sortKey="Paweska, J T" uniqKey="Paweska J">J.T. Paweska</name>
</author>
<author><name sortKey="Leman, P A" uniqKey="Leman P">P.A. Leman</name>
</author>
<author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name>
</author>
<author><name sortKey="Grywna, K" uniqKey="Grywna K">K. Grywna</name>
</author>
<author><name sortKey="Kemp, A" uniqKey="Kemp A">A. Kemp</name>
</author>
<author><name sortKey="Braack, L" uniqKey="Braack L">L. Braack</name>
</author>
<author><name sortKey="Sonnenberg, K" uniqKey="Sonnenberg K">K. Sonnenberg</name>
</author>
<author><name sortKey="Niedrig, M" uniqKey="Niedrig M">M. Niedrig</name>
</author>
<author><name sortKey="Swanepoel, R" uniqKey="Swanepoel R">R. Swanepoel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nal, B" uniqKey="Nal B">B. Nal</name>
</author>
<author><name sortKey="Chan, C" uniqKey="Chan C">C. Chan</name>
</author>
<author><name sortKey="Kien, F" uniqKey="Kien F">F. Kien</name>
</author>
<author><name sortKey="Siu, L" uniqKey="Siu L">L. Siu</name>
</author>
<author><name sortKey="Tse, J" uniqKey="Tse J">J. Tse</name>
</author>
<author><name sortKey="Chu, K" uniqKey="Chu K">K. Chu</name>
</author>
<author><name sortKey="Kam, J" uniqKey="Kam J">J. Kam</name>
</author>
<author><name sortKey="Staropoli, I" uniqKey="Staropoli I">I. Staropoli</name>
</author>
<author><name sortKey="Crescenzo Chaigne, B" uniqKey="Crescenzo Chaigne B">B. Crescenzo-Chaigne</name>
</author>
<author><name sortKey="Escriou, N" uniqKey="Escriou N">N. Escriou</name>
</author>
<author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S. van der Werf</name>
</author>
<author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name>
</author>
<author><name sortKey="Altmeyer, R" uniqKey="Altmeyer R">R. Altmeyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K. Narayanan</name>
</author>
<author><name sortKey="Maeda, A" uniqKey="Maeda A">A. Maeda</name>
</author>
<author><name sortKey="Maeda, J" uniqKey="Maeda J">J. Maeda</name>
</author>
<author><name sortKey="Makino, S" uniqKey="Makino S">S. Makino</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Netland, J" uniqKey="Netland J">J. Netland</name>
</author>
<author><name sortKey="Dediego, M L" uniqKey="Dediego M">M.L. DeDiego</name>
</author>
<author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name>
</author>
<author><name sortKey="Fett, C" uniqKey="Fett C">C. Fett</name>
</author>
<author><name sortKey="Alvarez, E" uniqKey="Alvarez E">E. Alvarez</name>
</author>
<author><name sortKey="Nieto Torres, J L" uniqKey="Nieto Torres J">J.L. Nieto-Torres</name>
</author>
<author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name>
</author>
<author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nguyen, V P" uniqKey="Nguyen V">V.-P. Nguyen</name>
</author>
<author><name sortKey="Hogue, B G" uniqKey="Hogue B">B.G. Hogue</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ortego, J" uniqKey="Ortego J">J. Ortego</name>
</author>
<author><name sortKey="Escors, D" uniqKey="Escors D">D. Escors</name>
</author>
<author><name sortKey="Laude, H" uniqKey="Laude H">H. Laude</name>
</author>
<author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ortego, J" uniqKey="Ortego J">J. Ortego</name>
</author>
<author><name sortKey="Ceriani, J E" uniqKey="Ceriani J">J.E. Ceriani</name>
</author>
<author><name sortKey="Patino, C" uniqKey="Patino C">C. Patino</name>
</author>
<author><name sortKey="Plana, J" uniqKey="Plana J">J. Plana</name>
</author>
<author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pervushin, K" uniqKey="Pervushin K">K. Pervushin</name>
</author>
<author><name sortKey="Tan, E" uniqKey="Tan E">E. Tan</name>
</author>
<author><name sortKey="Parthasarathy, K" uniqKey="Parthasarathy K">K. Parthasarathy</name>
</author>
<author><name sortKey="Lin, X" uniqKey="Lin X">X. Lin</name>
</author>
<author><name sortKey="Jiang, F L" uniqKey="Jiang F">F.L. Jiang</name>
</author>
<author><name sortKey="Yu, D" uniqKey="Yu D">D. Yu</name>
</author>
<author><name sortKey="Vararattanavech, A" uniqKey="Vararattanavech A">A. Vararattanavech</name>
</author>
<author><name sortKey="Soong, T W" uniqKey="Soong T">T.W. Soong</name>
</author>
<author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name>
</author>
<author><name sortKey="Torres, J" uniqKey="Torres J">J. Torres</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pinto, L H" uniqKey="Pinto L">L.H. Pinto</name>
</author>
<author><name sortKey="Holsinger, L J" uniqKey="Holsinger L">L.J. Holsinger</name>
</author>
<author><name sortKey="Lamb, R A" uniqKey="Lamb R">R.A. Lamb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Price, M P" uniqKey="Price M">M.P. Price</name>
</author>
<author><name sortKey="Thompson, R J" uniqKey="Thompson R">R.J. Thompson</name>
</author>
<author><name sortKey="Eshcol, J O" uniqKey="Eshcol J">J.O. Eshcol</name>
</author>
<author><name sortKey="Wemmie, J A" uniqKey="Wemmie J">J.A. Wemmie</name>
</author>
<author><name sortKey="Benson, C J" uniqKey="Benson C">C.J. Benson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quan, P L" uniqKey="Quan P">P.L. Quan</name>
</author>
<author><name sortKey="Firth, C" uniqKey="Firth C">C. Firth</name>
</author>
<author><name sortKey="Street, C" uniqKey="Street C">C. Street</name>
</author>
<author><name sortKey="Henriquez, J A" uniqKey="Henriquez J">J.A. Henriquez</name>
</author>
<author><name sortKey="Petrosov, A" uniqKey="Petrosov A">A. Petrosov</name>
</author>
<author><name sortKey="Tashmukhamedova, A" uniqKey="Tashmukhamedova A">A. Tashmukhamedova</name>
</author>
<author><name sortKey="Hutchison, S K" uniqKey="Hutchison S">S.K. Hutchison</name>
</author>
<author><name sortKey="Egholm, M" uniqKey="Egholm M">M. Egholm</name>
</author>
<author><name sortKey="Osinubi, M O" uniqKey="Osinubi M">M.O. Osinubi</name>
</author>
<author><name sortKey="Niezgoda, M" uniqKey="Niezgoda M">M. Niezgoda</name>
</author>
<author><name sortKey="Ogunkoya, A B" uniqKey="Ogunkoya A">A.B. Ogunkoya</name>
</author>
<author><name sortKey="Briese, T" uniqKey="Briese T">T. Briese</name>
</author>
<author><name sortKey="Rupprecht, C E" uniqKey="Rupprecht C">C.E. Rupprecht</name>
</author>
<author><name sortKey="Lipkin, W I" uniqKey="Lipkin W">W.I. Lipkin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raamsman, M J B" uniqKey="Raamsman M">M.J.B. Raamsman</name>
</author>
<author><name sortKey="Locker, J K" uniqKey="Locker J">J.K. Locker</name>
</author>
<author><name sortKey="De Hooge, A" uniqKey="De Hooge A">A. de Hooge</name>
</author>
<author><name sortKey="De Vries, A A F" uniqKey="De Vries A">A.A.F. de Vries</name>
</author>
<author><name sortKey="Griffiths, G" uniqKey="Griffiths G">G. Griffiths</name>
</author>
<author><name sortKey="Vennema, H" uniqKey="Vennema H">H. Vennema</name>
</author>
<author><name sortKey="Rottier, P J M" uniqKey="Rottier P">P.J.M. Rottier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rota, P A" uniqKey="Rota P">P.A. Rota</name>
</author>
<author><name sortKey="Oberste, M S" uniqKey="Oberste M">M.S. Oberste</name>
</author>
<author><name sortKey="Monroe, S S" uniqKey="Monroe S">S.S. Monroe</name>
</author>
<author><name sortKey="Nix, W A" uniqKey="Nix W">W.A. Nix</name>
</author>
<author><name sortKey="Campganoli, R" uniqKey="Campganoli R">R. Campganoli</name>
</author>
<author><name sortKey="Icenogle, J P" uniqKey="Icenogle J">J.P. Icenogle</name>
</author>
<author><name sortKey="Pe Aranda, S" uniqKey="Pe Aranda S">S. Peñaranda</name>
</author>
<author><name sortKey="Bankamp, B" uniqKey="Bankamp B">B. Bankamp</name>
</author>
<author><name sortKey="Maher, K" uniqKey="Maher K">K. Maher</name>
</author>
<author><name sortKey="Chen, M H" uniqKey="Chen M">M.-H. Chen</name>
</author>
<author><name sortKey="Tong, S" uniqKey="Tong S">S. Tong</name>
</author>
<author><name sortKey="Tamin, A" uniqKey="Tamin A">A. Tamin</name>
</author>
<author><name sortKey="Lowe, L" uniqKey="Lowe L">L. Lowe</name>
</author>
<author><name sortKey="Frace, M" uniqKey="Frace M">M. Frace</name>
</author>
<author><name sortKey="Derisi, J L" uniqKey="Derisi J">J.L. DeRisi</name>
</author>
<author><name sortKey="Chen, Q" uniqKey="Chen Q">Q. Chen</name>
</author>
<author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name>
</author>
<author><name sortKey="Erdman, D D" uniqKey="Erdman D">D.D. Erdman</name>
</author>
<author><name sortKey="Peret, T C T" uniqKey="Peret T">T.C.T. Peret</name>
</author>
<author><name sortKey="Burns, C" uniqKey="Burns C">C. Burns</name>
</author>
<author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name>
</author>
<author><name sortKey="Rollin, P E" uniqKey="Rollin P">P.E. Rollin</name>
</author>
<author><name sortKey="Sanchez, A" uniqKey="Sanchez A">A. Sanchez</name>
</author>
<author><name sortKey="Liffick, S" uniqKey="Liffick S">S. Liffick</name>
</author>
<author><name sortKey="Holloway, B" uniqKey="Holloway B">B. Holloway</name>
</author>
<author><name sortKey="Limor, J" uniqKey="Limor J">J. Limor</name>
</author>
<author><name sortKey="Mccaustland, K" uniqKey="Mccaustland K">K. McCaustland</name>
</author>
<author><name sortKey="Olsen Rassmussen, M" uniqKey="Olsen Rassmussen M">M. Olsen-Rassmussen</name>
</author>
<author><name sortKey="Fouchier, R" uniqKey="Fouchier R">R. Fouchier</name>
</author>
<author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name>
</author>
<author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A.D.M.E. Osterhaus</name>
</author>
<author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name>
</author>
<author><name sortKey="Pallansch, M A" uniqKey="Pallansch M">M.A. Pallansch</name>
</author>
<author><name sortKey="Anderson, L J" uniqKey="Anderson L">L.J. Anderson</name>
</author>
<author><name sortKey="Bellini, W J" uniqKey="Bellini W">W.J. Bellini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sawicki, S G" uniqKey="Sawicki S">S.G. Sawicki</name>
</author>
<author><name sortKey="Sawicki, D L" uniqKey="Sawicki D">D.L. Sawicki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schaecher, S R" uniqKey="Schaecher S">S.R. Schaecher</name>
</author>
<author><name sortKey="Mackenzie, J M" uniqKey="Mackenzie J">J.M. Mackenzie</name>
</author>
<author><name sortKey="Pekosz, A" uniqKey="Pekosz A">A. Pekosz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shen, S" uniqKey="Shen S">S. Shen</name>
</author>
<author><name sortKey="Lin, P S" uniqKey="Lin P">P.S. Lin</name>
</author>
<author><name sortKey="Chao, Y C" uniqKey="Chao Y">Y.C. Chao</name>
</author>
<author><name sortKey="Zhang, A" uniqKey="Zhang A">A. Zhang</name>
</author>
<author><name sortKey="Yang, X" uniqKey="Yang X">X. Yang</name>
</author>
<author><name sortKey="Lim, S G" uniqKey="Lim S">S.G. Lim</name>
</author>
<author><name sortKey="Hong, W" uniqKey="Hong W">W. Hong</name>
</author>
<author><name sortKey="Tan, Y J" uniqKey="Tan Y">Y.J. Tan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name>
</author>
<author><name sortKey="Van Der Meer, Y" uniqKey="Van Der Meer Y">Y. van der Meer</name>
</author>
<author><name sortKey="Zevenhoven Dobbe, J" uniqKey="Zevenhoven Dobbe J">J. Zevenhoven-Dobbe</name>
</author>
<author><name sortKey="Onderwater, J J" uniqKey="Onderwater J">J.J. Onderwater</name>
</author>
<author><name sortKey="Van Der Meulen, J" uniqKey="Van Der Meulen J">J. van der Meulen</name>
</author>
<author><name sortKey="Koerten, H K" uniqKey="Koerten H">H.K. Koerten</name>
</author>
<author><name sortKey="Mommaas, A M" uniqKey="Mommaas A">A.M. Mommaas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tooze, J" uniqKey="Tooze J">J. Tooze</name>
</author>
<author><name sortKey="Tooze, S A" uniqKey="Tooze S">S.A. Tooze</name>
</author>
<author><name sortKey="Fuller, S D" uniqKey="Fuller S">S.D. Fuller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Torres, J" uniqKey="Torres J">J. Torres</name>
</author>
<author><name sortKey="Parthasarathy, K" uniqKey="Parthasarathy K">K. Parthasarathy</name>
</author>
<author><name sortKey="Lin, X" uniqKey="Lin X">X. Lin</name>
</author>
<author><name sortKey="Saravanan, R" uniqKey="Saravanan R">R. Saravanan</name>
</author>
<author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Torres, J" uniqKey="Torres J">J. Torres</name>
</author>
<author><name sortKey="Maheswari, U" uniqKey="Maheswari U">U. Maheswari</name>
</author>
<author><name sortKey="Parthasarathy, K" uniqKey="Parthasarathy K">K. Parthasarathy</name>
</author>
<author><name sortKey="Ng, L" uniqKey="Ng L">L. Ng</name>
</author>
<author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name>
</author>
<author><name sortKey="Gong, X" uniqKey="Gong X">X. Gong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Hoek, L" uniqKey="Van Der Hoek L">L. van der Hoek</name>
</author>
<author><name sortKey="Pyrc, K" uniqKey="Pyrc K">K. Pyrc</name>
</author>
<author><name sortKey="Jebbink, M F" uniqKey="Jebbink M">M.F. Jebbink</name>
</author>
<author><name sortKey="Vermeulen Oost, W" uniqKey="Vermeulen Oost W">W. Vermeulen-Oost</name>
</author>
<author><name sortKey="Berkhout, R J" uniqKey="Berkhout R">R.J. Berkhout</name>
</author>
<author><name sortKey="Wolthers, K C" uniqKey="Wolthers K">K.C. Wolthers</name>
</author>
<author><name sortKey="Wertheim Van Dillen, P M" uniqKey="Wertheim Van Dillen P">P.M. Wertheim-van Dillen</name>
</author>
<author><name sortKey="Kaandorp, J" uniqKey="Kaandorp J">J. Kaandorp</name>
</author>
<author><name sortKey="Spaargaren, J" uniqKey="Spaargaren J">J. Spaargaren</name>
</author>
<author><name sortKey="Berkhout, B" uniqKey="Berkhout B">B. Berkhout</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Most, R G" uniqKey="Van Der Most R">R.G. van der Most</name>
</author>
<author><name sortKey="Spaan, W J M" uniqKey="Spaan W">W.J.M. Spaan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weiss, S R" uniqKey="Weiss S">S.R. Weiss</name>
</author>
<author><name sortKey="Navas Martin, S" uniqKey="Navas Martin S">S. Navas-Martin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilson, L" uniqKey="Wilson L">L. Wilson</name>
</author>
<author><name sortKey="Mckinlay, C" uniqKey="Mckinlay C">C. McKinlay</name>
</author>
<author><name sortKey="Gage, P" uniqKey="Gage P">P. Gage</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilson, L" uniqKey="Wilson L">L. Wilson</name>
</author>
<author><name sortKey="Gage, P" uniqKey="Gage P">P. Gage</name>
</author>
<author><name sortKey="Ewart, G" uniqKey="Ewart G">G. Ewart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wong, S K" uniqKey="Wong S">S.K. Wong</name>
</author>
<author><name sortKey="Li, W" uniqKey="Li W">W. Li</name>
</author>
<author><name sortKey="Moore, M J" uniqKey="Moore M">M.J. Moore</name>
</author>
<author><name sortKey="Choe, H" uniqKey="Choe H">H. Choe</name>
</author>
<author><name sortKey="Farzan, M" uniqKey="Farzan M">M. Farzan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wozniak, A L" uniqKey="Wozniak A">A.L. Wozniak</name>
</author>
<author><name sortKey="Griffin, S" uniqKey="Griffin S">S. Griffin</name>
</author>
<author><name sortKey="Rowlands, D" uniqKey="Rowlands D">D. Rowlands</name>
</author>
<author><name sortKey="Harris, M" uniqKey="Harris M">M. Harris</name>
</author>
<author><name sortKey="Yi, M" uniqKey="Yi M">M. Yi</name>
</author>
<author><name sortKey="Lemon, S M" uniqKey="Lemon S">S.M. Lemon</name>
</author>
<author><name sortKey="Weinman, S A" uniqKey="Weinman S">S.A. Weinman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yuan, Q" uniqKey="Yuan Q">Q. Yuan</name>
</author>
<author><name sortKey="Liao, Y" uniqKey="Liao Y">Y. Liao</name>
</author>
<author><name sortKey="Torres, J" uniqKey="Torres J">J. Torres</name>
</author>
<author><name sortKey="Tam, J P" uniqKey="Tam J">J.P. Tam</name>
</author>
<author><name sortKey="Liu, D X" uniqKey="Liu D">D.X. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name>
</author>
<author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name>
</author>
<author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A.E. Gorbalenya</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zu Iga, S" uniqKey="Zu Iga S">S. Zuñiga</name>
</author>
<author><name sortKey="Cruz, J L" uniqKey="Cruz J">J.L. Cruz</name>
</author>
<author><name sortKey="Sola, I" uniqKey="Sola I">I. Sola</name>
</author>
<author><name sortKey="Mateos Gomez, P A" uniqKey="Mateos Gomez P">P.A. Mateos-Gomez</name>
</author>
<author><name sortKey="Palacio, L" uniqKey="Palacio L">L. Palacio</name>
</author>
<author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Espagne</li>
<li>Singapour</li>
</country>
<region><li>Communauté de Madrid</li>
</region>
<settlement><li>Madrid</li>
</settlement>
<orgName><li>Université autonome de Madrid</li>
</orgName>
</list>
<tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Nieto Torres, Jose L" sort="Nieto Torres, Jose L" uniqKey="Nieto Torres J" first="Jose L." last="Nieto-Torres">Jose L. Nieto-Torres</name>
</region>
<name sortKey="Alvarez, Enrique" sort="Alvarez, Enrique" uniqKey="Alvarez E" first="Enrique" last="Álvarez">Enrique Álvarez</name>
<name sortKey="Dediego, Marta L" sort="Dediego, Marta L" uniqKey="Dediego M" first="Marta L." last="Dediego">Marta L. Dediego</name>
<name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name>
<name sortKey="Jimenez Guarde O, Jose M" sort="Jimenez Guarde O, Jose M" uniqKey="Jimenez Guarde O J" first="Jose M." last="Jiménez-Guarde O">Jose M. Jiménez-Guarde O</name>
<name sortKey="Kremer, Leonor" sort="Kremer, Leonor" uniqKey="Kremer L" first="Leonor" last="Kremer">Leonor Kremer</name>
<name sortKey="Llorente, Mercedes" sort="Llorente, Mercedes" uniqKey="Llorente M" first="Mercedes" last="Llorente">Mercedes Llorente</name>
<name sortKey="Regla Nava, Jose A" sort="Regla Nava, Jose A" uniqKey="Regla Nava J" first="Jose A." last="Regla-Nava">Jose A. Regla-Nava</name>
</country>
<country name="Singapour"><noRegion><name sortKey="Shuo, Shen" sort="Shuo, Shen" uniqKey="Shuo S" first="Shen" last="Shuo">Shen Shuo</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002036 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002036 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4726981 |texte= Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21524776" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
This area was generated with Dilib version V0.6.33. |